Lecapon-Mepha 100mg / 25mg / 200mg 100 film-coated tablets

<style>.h {font-size: 14px !important;font-family: Verdana,sans-serif;font-weight: bold !important ;}div#desc h3,p,li,ul {font-size: 14px !important;}.- mt-1,#777,#pText, .markup pb-2.5{font-family: Verdana; font-size: 14px;}</style><p></p><div id="777"><div class="- mt-1"> <ul><li> <div class="paragraph"> <h3> <div class="h"> </div><div class="h"><br></div><div class="h"><br></div><div class="h"><br></div><div class="h">What is Lecapon-Mepha and when is it used? </div> </h3> <p> As prescribed by your doctor. </p> <p> Lecapon-Mepha is used to treat patients with Parkinson's Disease used that suffer from certain symptoms (fluctuating motor symptoms, so-called end dose or <em> «on-off» </em> symptoms). Lecapon-Mepha is used when the symptoms have not been adequately stabilized under previous therapy with one or two active ingredients. </p> <p> Lecapon-Mepha is a combination of three active substances in one lactab. </p>&nbsp;<span style="font-size: 14px;">Every Lactab Lecapon-Mepha contains levodopa as a component that works against Parkinson's disease. In addition, each lactab contains carbidopa and entacapone. These improve the effect of relieving the Parkinson's symptoms of levodopa.</span> <p></p> </div> <div class="paragraph"> <h3> <div class="h"> When should Lecapon-Mepha not be taken? <!-- Div --> </div></h3> <p> Lecapon-Mepha must not be taken if: </p> <ul class="list-bullets"> <li> you are hypersensitive to the active ingredients levodopa, carbidopa, entacapone or any of the other ingredients of Lecapon-Mepha. </li> <li> You have liver disease. </li> <li> You suffer from increased intraocular pressure due to glaucoma (glaucoma). </li> <li> You have suffer from pheochromocytoma (a tumor of the adrenal gland), as this can increase the risk of severe increases in blood pressure. </li> <li> You are also taking certain antidepressants (selective MAO-A and MAO-B inhibitors in combination or non-selective MAO- Inhibitors). </li> <li> You have developed neuroleptic malignant syndrome (NOS) and / or non-traumatic rhabdomyolysis (a rare type of muscle disorder) ten is. </li> <li> You have or have a melanoma. or have a suspicious, previously undiagnosed skin lesion. </li> <li> You are under 18 years of age. </li> </ul> </div> <div class="paragraph"> <h3> <div class="h"> When should you be careful when taking Lecapon-Mepha? </div> </h3> <h4> <div class="h"> Take care when taking Lecapon-Mepha: <!-- div--> </div></h4> <ul class="list-bullets"> <li> If you have had a heart attack or any other disease of the cardiovascular system or the lungs, bronchial asthma, a kidney or an endocrine disorder, or under have a special type of involuntary movement (called extrapyramidal disorder), have had a stomach ulcer or seizure, or inflammatory bowel disease. Patients who have suffered from a gastric or intestinal ulcer may have an increased likelihood of gastrointestinal bleeding. Tell your doctor. </li> <li> If you feel depressed or have thoughts of suicide, or if you notice unusual changes in your behavior, you should see your doctor. </li> <li> If you have an elevated Have intraocular pressure due to chronic wide-angle glaucoma. The dose of Lecapon-Mepha may need to be adjusted and your intraocular pressure monitored. </li> <li> If you are taking other medicines that can occasionally cause a drop in blood pressure (orthostatic hypotension), as Lecapon-Mepha can intensify such reactions. <!-- li--> </li><li> If involuntary movements occur or worsen after starting treatment with Lecapon-Mepha, you should consult your doctor, as the dosage of your medication may have to be adjusted. </li> <li> If If you notice severe muscle stiffness, severe muscle twitching, severe muscle pain or weakness, tremors, restlessness, confusion, fever, rapid heartbeat or large fluctuations in blood pressure, you should contact your doctor immediately. </li> <li> If you stop using Lecapon-Mepha this should only be done in consultation with your doctor, as Lecapon-Mepha may be slowly discontinued and the dose of your other medicines may be reduced Parkinson's disease needs adjustment to avoid worsening of your Parkinson's symptoms or side effects. </li> <li> If you have increased diarrhea, you should check your body weight regularly; If you notice any noticeable weight loss, your doctor should be informed. </li> <li> If you develop progressive loss of appetite, exhaustion (asthenia) and weight loss within a relatively short period of time. In this case, a full medical evaluation should be considered. </li> <li> If you, family members, or caregivers notice that you are developing addiction-like symptoms that lead to cravings, tell your doctor or health care professional Cans of Lecapon-Mepha and otherser medicines used to treat Parkinson's disease (known as dopamine dysregulation syndrome). </li> <li> If you, family members, or caregivers notice that you are developing an urge or desire to be in a If you behave in ways that are unusual for you, or if you cannot resist the urge, urge or urge to perform certain actions that may be harmful to you or others, talk to your doctor. Such behaviors are known as impulse control disorders and can include gambling addiction, eating or shopping addiction, abnormally increased sexual desire, or overuse of sexual thoughts or feelings. Your doctor may need to review your treatment. </li> </ul> <p> Lecapon-Mepha may cause dizziness or mild headaches due to a drop in blood pressure. This can affect the ability to react, drive and use tools or machines. </p> <p> In rare cases drowsiness and sudden sleep may occur during treatment. The latter can sometimes occur without warning or drowsiness. If you suddenly fall asleep or are very drowsy during the day, you must therefore not drive or engage in other activities (e.g. use tools or machines) while taking Lecapon-Mepha, in which reduced alertness endangers you or others. You should refrain from driving a vehicle, such as the activities mentioned above, until you have sufficient experience with the use of the drug and can rule out the possible occurrence of these impairments with sufficient certainty. </p> <h4> <div class="h"> Taking other medicines: </div> </h4> <p> Lecapon-Mepha can influence the effects and side effects of many other medicines. Conversely, the effects and side effects of Lecapon-Mepha can be influenced by other medicines. </p> <p> It is particularly important that you tell your doctor which medicines (including those you bought yourself or herbal ones) you are currently using are taking or have recently taken. </p> <h4> <div class="h"> An intensification of the effects and side effects of the following drugs by Lecapon-Mepha is possible with: </div> </h4> <ul class="list-bullets"> <li> Certain mood-enhancing drugs (antidepressants) of the type of tricyclic antidepressants, MAO-A inhibitors, norepinephrine reuptake inhibitors (active ingredients such as maprotiline and venlafaxine). </li> <li> Medicinal products with the following active ingredients : Paroxetine, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa and apomorphine. </li> </ul> <h4> <div class="h"> The following medicines can reduce the effect of Lecapon-Mepha : </div> </h4> <ul class="list-bullets"> <li> Besti mmed drugs used to treat psychosis or schizophrenia [e.g. Phenothiazines (e.g. active ingredients such as levomepromazine, thioridazine, fluphenazine) and butyrophenones (e.g. haloperidol)]. </li> <li> Certain drugs used to treat nausea and vomiting (such as metoclopramide). </li> <li> As well as drugs for Prevention of seizures (epilepsy) with phenytoin and medicines containing papavarin. </li> </ul> <p> Therefore, you must tell your doctor or health care professional if you are taking these medicines and / or if Lecapon- Notice Mepha. </p> <p> Lecapon-Mepha can impair the absorption of iron through the gastrointestinal tract. Therefore, Lecapon-Mepha should be taken and iron-containing medicines should be taken at least 2-3 hours apart. </p> <p> Please only take Lecapon-Mepha after consulting your doctor, if you know that you are intolerant to sugar. </p> <p> Lecapon-Mepha 100/25/200 mg Lactab contains the azo dye Allura Red AC (E129) and Lecapon-Mepha 150 / 37.5 / 200 mg Lactab contains the Azo dye azorubine (E122). These can cause allergic reactions. </p> <p> Tell your doctor or pharmacist if you </p> <ul class="list-bullets"> <li> suffer from other diseases, </li> <li> Have allergies or </li> <li> take or apply other medicines (including ones you have bought yourself!). </li> </ul> </div> <div class="paragraph"> <h3> <div class="h"> Can Lecapon-Mepha be taken during pregnancy or while breastfeeding? </div> </h3> <p> Lecapon-Mepha must not be used during pregnancy. <!-- p --> </p><p> Women are not allowed to breastfeed during treatment with Lecapon-Mepha. </p> </div> <div class="paragraph"> <h3> <div class="h"> How do you use Lecapon-Mepha? </div> </h3> <p> A Lactab Lecapon-Mepha contains one treatment dose each. Take only one Lactab Lecapon-Mepha at a time. You should not take 2 or more Lactab Lecapon-Mepha at one time. Do not share the lactab. </p> <p> You should strictly follow your doctor's instructions when taking Lecapon-Mepha, other medicines containing levodopa, and other medicines for Parkinson's disease . This includes following the instructions on when and how to take your medicine. </p> <p> Do not change the prescribed dosage on your own. If you think the medicine is too weak or too strong, talk to your doctor or pharmacist. </p> <p> You should not start treatment with Lecapon-Mepha without extensive prior advice from your doctor Do not take Lecapon-Mepha together or shortly before or after a very protein-rich meal (e.g. lots of meat, fish, cheese and eggs), as the consumption of one Active ingredient of Lecapon-Mepha can be impaired. Lecapon-Mepha and iron supplements should be taken at least 2-3 hours apart. </p> <p> If you accidentally take too much Lactab Lecapon-Mepha, you should contact your doctor or pharmacist immediately or speak to a pharmacist. </p> <p> As soon as you realize that you have forgotten to take Lecapon-Mepha, you should do so. However, two Lactab Lecapon-Mepha should not be taken within the same hour. You should also not take a double dose to make up for a forgotten single dose. You should then resume your usual dosage regimen. </p> <p> The use and safety of Lecapon-Mepha in children and adolescents under 18 years of age has not been tested. No data is available. Lecapon-Mepha must not be taken by children and adolescents. </p> </div> <ul><ul><ul><li> <h3> <div class="h"> What side effects can Lecapon-Mepha have? <!-- Div --> </div></h3> <p> The following side effects can occur when taking Lecapon-Mepha: </p> <p> Lecapon-Mepha is a combination of levodopa, carbidopa and entacapone in one preparation. Therefore, the side effects described for treatment with levodopa / carbidopa and the combination of entacapone together with levodopa / carbidopa can also occur with Lecapon-Mepha. </p> <h4> <div class="h"> Very common (affects more than one in 10 users) </div> </h4> <ul><li>involuntary movements mostly of the arms, legs or head (dyskinesia); Nausea; </li></ul> <ul><li> diarrhea; </li><li> harmless reddish-brown discoloration of the urine; </li><li> muscle pain, pain in the musculoskeletal system. </li></ul> <h4> <div class="h"> Common (affects 1 to 10 users in 100) </div> </h4> <ul><li>skin rash, increased sweating; </li></ul> <ul><li>worsening of Parkinson's symptoms, tremors (tremor), changing mobility / Ability to move in Parkinson's disease with alternation between rigid motion ("off state") and mobility ("on state"), involuntary muscle tension (dystonia); </li><li> psychological changes such as disorders of mental performance with e.g. memory / retentive disorders, dementia; </li><li> drowsiness, drowsiness / dizziness, headache; </li><li> complaints in connection with diseased coronary arteries (coronary heart disease) such as sudden feeling of tightness / pressure / pain in chest (angina pectoris), irregular heartbeat (irregular heartbeat), dizziness or fainting due to low blood pressure (blood pressure drop) all) when standing up; increased blood pressure; </li><li> shortness of breath, shortness of breath; </li><li> depression (possibly with suicidal ideation), delusions (hallucinations), confusion, abnormal dreams including nightmares, anxiety and insomnia; </li><li>muscle cramps, joint pain; </li><li> anemia; </li><li> weight loss, loss of appetite, inflammation of the urinary tract (e.g. cystitis), dry mouth, vomiting, abdominal pain and discomfort in the upper abdomen, constipation , Heartburn; </li><li> swollen legs, gait disorder, frequent falls, weakness, fatigue; </li><li> blurred vision. </li></ul> <h4> <div class="h"> occasionally (affects 1 up to 10 out of 1000 users) </div> </h4> <ul><li> myocardial infarction; </li></ul> <ul><li> gastrointestinal bleeding; </li><li> lack of blood platelets (thrombocytopenia) with impaired blood clotting (e.g. after Injuries, it takes longer than usual for the bleeding to stop, or bruises appear more quickly or without external influence); </li><li>psychotic Sy mptome, restlessness; </li><li>colon inflammation; </li><li> difficulty swallowing; </li><li> liver values ​​outside the norm in blood tests; </li><li> discoloration of the skin, nails, hair , sweat; </li><li> inability to urinate (urinary retention); </li><li> general malaise. </li></ul> <h4> <div class="h"> Other side effects are: </div> </h4> <p> Hypersensitivity reactions can occur. The signs may include: hives (hives), itching, skin rash, punctiform bleeding in the skin, sudden and often rapid swelling of the face, lips, tongue or throat (this can make it difficult to breathe or swallow). If you experience such hypersensitivity reactions, you must contact your doctor immediately. </p> <p> Lecapon-Mepha 100 mg / 25 mg / 200 mg lactab and Lecapon-Mepha 150 mg / 37.5 mg / 200 mg lactab can trigger hypersensitivity reactions of the skin and respiratory organs due to the azo dyes it contains, especially in patients with asthma, nettle rash (chronic urticaria) or with hypersensitivity to acetylsalicylic acid and other rheumatic and pain relievers (see “When to take Lecapon-Meph Caution advised? »). </p> <p> There may be excessive tiredness / sleepiness during the day and sudden uncontrolled attacks of falling asleep (see« When should you take caution when taking Lecapon-Mepha? »). </p>Liver inflammation with jaundice can occur. <p></p> <p> Very rarely, a so-called neuroleptic malignant syndrome is caused, which is mainly characterized by fever, impaired consciousness and M. expresses muscle stiffness. Very rarely, you will experience severe muscle pain or weakness, which can be signs of severe muscle breakdown (rhabdomyolysis). In both cases, the attending physician must be contacted immediately. </p> <h4> <div class="h"> You may experience the following side effects: </div> </h4> <ul class="list-bullets"> <li> The desire for high doses of Lecapon-Mepha that exceed the doses required to control motor symptoms, the so-called dopamine dysregulation syndrome. Some patients experience severe uncontrolled movements (dyskinesia), mood changes, or other side effects after taking high doses of Lecapon-Mepha. </li> <li> Inability to resist the impulse to take an action that could be harmful ; These include: </li> <li> a strong impulse to gamble excessively despite significant or personal, family consequences, </li> <li> changed or increased sexual interest and behavior that is worrying for you or others, for example a increased sex drive, </li> <li> uncontrollable, excessive shopping and spending, </li> <li> binge eating (eating large amounts in a short period) or compulsive eating (eating more than normal and more than necessary to satisfy hunger). </li> </ul> <p> Notify your doctor or health care professional if you experience any of these behavior patterns; Your doctor will discuss ways to deal with or reduce these symptoms. </p> <p> If you get any side effects, talk to your doctor or pharmacist. This applies in particular to side effects that are not listed in this leaflet. </p> </li></ul></ul></ul> <div class="paragraph"> <h3> <div class="h"> What else should you watch out for? <!-- div--> </div></h3> <p> The medicinal product may only be used up to the date marked «EXP» on the container. </p> <h4> <div class="h"> Storage information </div> <!-- h4--> <p> Store in the original packaging and not above 25 ° C. Keep out of the reach of children. </p> </h4><h4> <div class="h"> Further information </div> </h4> <p> Your doctor or pharmacist can provide you with further information. These persons have the detailed specialist information at their disposal. </p> </div> <ul><ul><ul><ul><li> <h3> <div class="h"> What does Lecapon-Mepha contain? </div> <!-- h3 --> </h3><h4> <div class="h"> Active ingredients </div> </h4> <ul><li> <em> Lecapon-Mepha 50 mg / 12.5 mg / 200 mg, Lactab </em>: 50 mg levodopa, 12.5 mg carbidopa, 200 mg entacapone. </li></ul> <ul><li> <em> Lecapon-Mepha 75 mg / 18.75 mg / 200 mg, lactab </em>: 75 mg levodopa, 18.75 mg carbidopa, 200 mg entacapone. <!-- p --> </li><li> <em> Lecapon-Mepha 100 mg / 25 mg / 200 mg, Lactab </em>: 100 mg levodopa, 25 mg carbidopa, 200 mg entacapone. </li></ul> <ul><li> <em> Lecapon-Mepha 125 mg / 31.25 mg / 200 mg, Lactab </em>: 125 mg levodopa, 31.25 mg carbidopa, 200 mg entacapone. </li><li> <em> Lecapon-Mepha 150 mg / 37.5 mg / 200 mg, lactab </em>: 150 mg levodopa, 37.5 mg carbidopa, 200 mg entacapone. </li><li> <em> Lecapon-Mepha 200 mg / 50 mg / 200 mg, lactab </em>: 200 mg levodopa, 50 mg carbidopa, 200 mg entacapone. </li></ul> <h4> <div class="h"> Excipients </div> </h4> <h4> <div class="h"> Tablet core (all dose strengths): <!-- div--> </div></h4> <p> Microcrystalline e Cellulose, lactose, low-substituted hydroxypropyl cellulose, povidone, highly dispersed silicon dioxide, magnesium stearate. </p> <h4> <div class="h"> Tablet film: </div> </h4> <ul><li> <em> Lecapon-Mepha 50 mg / 12.5 mg / 200 mg: </em> titanium dioxide (E171), hypromellose, Glycerol, polysorbate 80, magnesium stearate, iron oxide yellow (E172), iron oxide red (E172), iron oxide black (E172). </li></ul> <ul><li> <em> Lecapon-Mepha 75 mg / 18.75 mg / 200 mg: <!-- em --> Titanium dioxide (E171), hypromellose, glycerol, polysorbate 80, magnesium stearate, yellow iron oxide (E172), red iron oxide (E172). </em></li></ul><em> <ul><li> <em> Lecapon-Mepha 100 mg / 25 mg / 200 mg: &lt; / em&gt; Titanium dioxide (E171), hypromellose, glycerol, polysorbate 80, magnesium stearate, 2.11 mg allura red AC (E129), carminic acid (E120). </em></li></ul><em> <ul><li> <em> Lecapon-Mepha 125 mg / 31.25 mg / 200 mg: </em> titanium dioxide (E171), hypromellose, glycerol, polysorbate 80, magnesium stearate, iron oxide yellow (E172), iron oxide red (E172). </li><li> <em> Lecapon-Mepha 150 mg / 37.5 mg / 200 mg: </em> titanium dioxide (E171), hypromellose, glycerol, polysorbate 80, magnesium stearate, red iron oxide (E172), 2.88 mg azorubine (E122). </li><li> <em> Lecapon-Mepha 200 mg / 50 mg / 200 mg: </em> titanium dioxide (E171), hypromellose, glycerol, polysorbate 80, magnesium stearate, yellow iron oxide (E172), red iron oxide (E172), black iron oxide rz (E1</li></ul></em></em></li></ul></ul></ul></ul><em><em> <div class="paragraph"> <h3> <div class="h"> Where can you get Lecapon-Mepha? Which packs are available? </div> </h3> <p> In pharmacies only with a doctor's prescription. </p> <p> Lecapon-Mepha is available in two pack sizes, each 30 or 100 Lactab contain.</p><ul><li>Lecapon-Mepha Lactab 100mg / 25mg / 200mg 100 pcs<br></li><li>Lecapon-Mepha Lactab 100mg / 25mg / 200mg 30 pcs<br></li></ul><p> </p> </div> <div class="paragraph"> <h3> <div class="h"> Marketing authorization holder </div> </h3> <p> Mepha Pharma AG, Basel.&nbsp;</p></div> <div class="paragraph"> <p><br><span style="font-family: Verdana;"></span><span style="font-family: Verdana;"></span><span style="font-family: Verdana;"></span><span style="font-family: Verdana;"></span></p></div></em></em></li></ul></div></div>